Second nifedipine a calcium channel blocker attenuated hg induced caspase 3 activation and lamin b degradation in islet β cells suggesting that calcium overload could be causal to hg induced nuclear alterations. Although it is well known that caspase 6 can cleave lamin a adjacent to the sequence veid takahashi et al 1996a little is known about the role s of. Inhibition of caspase activity revealed that the bulk of the lamin b both b1 and b2 was mislocalized to the cytoplasm excluding the trivial possibility that failure to incorporate lamin b into the nuclear lamina was due to lamin degradation.
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